Zyloprin 300mg 20 Tabs, Alopurinol
INDICATIONS:Zyloprim ® is indicated to reduce the formation of uric acid and urate in conditions in which they have submitted deposits (gouty arthritis, tophi leather, nephrolithiasis) or predictable clinical risk exists, for example, when the treatment of certain malignanciescan produce acute uric acid nephropathy.
The main clinical entities that can occur in the deposits of uric acid or urates are:
- Drop idiopathic.
- Uric acid lithiasis.
- Acute uric acid nephropathy.
- Neoplastic disease and myeloproliferative disease with high cell turnover, in which they have high levels of urate, either spontaneously or after cytotoxic therapy.
- Overproduction of urate caused by certain enzymatic alterations as hypoxanthine guanine phosphoribosyl transferase including Lesch-Nyhan syndrome, glucose-6-phosphatase (glycogen storage disease), fosforribosilpirofosfato synthase-amidotransferase fosforribosilpirofosfato and adenine phosphoribosyl- transferase.
Zyloprim ® is indicated for the management of kidney stones by 2.8-dihydroxyadenine (2,8-DHA) related to deficient activity of adenine phosphoribosyl transferase. Also indicated in the management of recurrent kidney stones calcium oxalate mixed in the presence of hyperuricosuria, when dietary measures have failed and fluid intake.
CONTRAINDICATIONS: Zyloprim ® should not be administered in patients with known hypersensitivity to allopurinol or any component of the formulation.
DOSAGE AND ADMINISTRATION: Oral.
Avoid splitting the tablets.
Adults: Zyloprim ® is started at low doses, 100 mg / day to reduce the risk of adverse reactions. Doses are increased only if the serum urate response is inadequate. Extreme care must be taken if the renal function is impaired (see Dosage in the presence of kidney damage).
We suggest the following dosing schedules: 100 to 200 mg per day in mild cases, 300 to 600 mg per day in moderately severe cases, 700 to 900 mg per day in severe cases.
Weight dose is 2 to 10 mg / kg / day.
Under 15 years: 10 to 20 mg / kg / day, up to 400 mg a day. The use in children is rarely indicated except malignancies (especially leukemia) and certain enzyme disorders such as Lesch-Nyhan syndrome.
Elderly: In the absence of specific data, you should use the lowest dose that produces satisfactory urate reduction.
Particular attention to the dosing recommendations in renal failure and general precautions.
Name of the medication:Puribel-300
Comparative brand name Zyloprim
Active substance: Alopurinol
Concentration: 300 mg
Time release: No
Laboratory: Bruluart, S.A. de C.V
Bottle with 20 pills
Made in: Mexico